Efficacy and safety of sericin hydrogel patch containing methyl salicylate and menthol for analgesic in muscle pain volunteers

ประสิทธิภาพและความปลอดภัยของแผ่นแปะไฮโดรเจลจากโปรตีนกาวไหมผสมเมทิลซาลิซิเลตและเมนทอลเพื่อบรรเทาอาการปวดในอาสาสมัครปวดเมื่อยกล้ามเนื้อ

  • Pornanong Aramwit Chulalongkorn University
  • Ariya Ariya Sarikaphuti
  • Supamas Napavichayanun
Keywords: Analgesic patch, Hydrogel, Sericin, Efficacy, Safety

Abstract

The use of an analgesic patch is not only to alleviate pain but also to avoid adverse events of drug administration. Sericin hydrogel patch is soft and flexible. It also has a cooling effect resulting in comfortable feeling. Moreover, the hydrogel is composed of sericin which provides an anti-inflammatory activity. It also contains methyl salicylate and menthol which have an analgesic activity. The objectives of this study were to investigate efficacy and safety of sericin hydrogel patch containing methyl salicylate and menthol for its analgesic effect in 47 muscle pain volunteers. The hydrogel was covered on pain area for 3 days (2 times a day) comparing to commercial available patch containing 0.4% menthol. The result showed that mean pain score after receiving sericin hydrogel patch significantly decreased comparing to mean pain score before applying the hydrogel (p < 0.05). However, the pain score after receiving sericin hydrogel patch and commercial patch were not significant difference. In addition, side effect of sericin hydrogel patch was not found. In conclusion, sericin hydrogel patch had analgesic effect similar to commercial available pain relief patch. It was safe and might be an alternative product for muscle pain relief.

Published
2019-06-30